Hodgkin's Disease Confined to Jejunum

Castleman's disease confined to the leptomeninges.

We report a rare case of the plasma cell variant of Castleman's disease confined to the leptomeninges in a 42-year-old female. Flow cytometry demonstrated a minor monoclonal kappa light chain population, and conventional Southern blotting confirmed clonal rearrangement of the J(H) immunoglobulin heavy-chain gene. Polymerase chain reaction for Epstein-Barr virus and Kaposi's sarcoma-associated h...

Whipple's disease confined to the nervous system.

Whipple's disease confined to the nervous system occurred in a 36-year old woman who presented with grand mal seizures and dementia. There was no evidence of extracerebral involvement and the jejunal biopsy was negative before treatment. Multiple enhancing lesions on CT scan progressed despite therapy with minocycline and prednisone, but resolved on treatment with tetracycline. The dementia did...

The Hodgkins Fund Prizes

Viral-related RNA in Hodgkins' disease and other human lymphomas.

Molecular hybridization with radioactively labeled DNA complementary to the RNA of the Rauscher leukemia virus was used to probe for homologous RNA in human lymphomas. 22 of 32 specimens contained RNA possessing homology to the RNA of the mouse leukemia virus, but not to that of the unrelated viruses causing mammary tumors in mice or myeloblastosis in chickens. Normal adult and fetal tissues fa...

Motor neuron disease and its association with non-Hodgkins lymphoma.

M otor neuron disease (MND) is a neurodegenerative disorder characterized by muscle atrophy, brisk reflexes, spasticity, fasciculation, and atrophy. The onset of the disease is generally insidious. The pathological process may involve the motor cortex, the spinal cord, and the brainstem. 1 Only upper or only lower motor neurons may be affected. The disease may or may not be seen with neoplasms,...